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UAL Research Online

New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation.

Gregorí Valdes, Barbara and Serro, Ana Paula and Gordo, Paulo and Silva, Alexandra and Gonçalves, Lídia and Salgado, Ana and Marto, Joana and Baltazar, Diogo and Galhano dos Santos, Rui and Moura Bordado, Joao and Ribeiro, Helena Margarida (2017) New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation. Journal of Pharmaceutical Sciences, 106. pp. 1570-1577. ISSN 0022-3549

Type of Research: Article
Creators: Gregorí Valdes, Barbara and Serro, Ana Paula and Gordo, Paulo and Silva, Alexandra and Gonçalves, Lídia and Salgado, Ana and Marto, Joana and Baltazar, Diogo and Galhano dos Santos, Rui and Moura Bordado, Joao and Ribeiro, Helena Margarida
Description:

Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. The aim of this work has been the development of new PU-based nail lacquers with antifungal activity containing 1.0% (wt/wt) of terbinafine hydrochloride. The biocompatibility, wettability, and the prediction of the free volume in the polymeric matrix were assessed using a human keratinocytes cell line, contact angle, and Positron Annihilation Lifetime Spectroscopy determinations, respectively. The morphology of the films obtained was confirmed by scanning electron microscopy, while the nail lacquers’ bioadhesion to nails was determined by mechanical tests. Viscosity, in vitro release profiles, and antifungal activity were also assessed. This study demonstrated that PU terbinafine based nail lacquers have good keratinocyte compatibility, good wettability properties, and adequate free volume. They formed a homogenous film after application, with suitable adhesion to the nail plate. Furthermore, the antifungal test results demonstrated that the terbinafine released from the nail lacquer Formulation A PU 19 showed activity against dermatophytes, namely Trichophyton rubrum.

Official Website: http://jpharmsci.org/article/S0022-3549(17)30126-0/fulltext
Additional Information (Publicly available):

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Keywords/subjects not otherwise listed: Pharmaceutics, Pharmacology
Publisher/Broadcaster/Company: Elsevier Inc.
Your affiliations with UAL: Colleges > London College of Fashion
Date: June 2017
Digital Object Identifier: 10.1016/j.xphs.2017.02.017
Related Websites:
Date Deposited: 17 Jul 2017 12:49
Last Modified: 19 Jul 2017 00:26
Item ID: 11157
URI: https://ualresearchonline.arts.ac.uk/id/eprint/11157

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