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The role of vehicle–nanoparticle interactions in topical drug delivery

Moddaresi, Mojgan and Brown, Marc B. and Zhao, Yanjun and Tamburic, Slobodanka and Jones, Stuart A. (2010) The role of vehicle–nanoparticle interactions in topical drug delivery. International Journal of Pharmaceutics, 400 (1-2). pp. 176-182. ISSN 0378-5173 [Physical Sciences > Cosmetic Science]
 
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Creators:Moddaresi, Mojgan and Brown, Marc B. and Zhao, Yanjun and Tamburic, Slobodanka and Jones, Stuart A.
Description:

Loading ‘difficult to deliver’ therapeutic agents into lipid nanoparticles (LN) is an attractive means to administer them to the skin. However, employing colloidal carriers to administer therapeutic agents from semi-solid preparations adds an extra dimension to the already complex process of topical drug delivery. The aim of this work was to understand how the mobility of nanoparticles influenced the delivery of a model drug when the carriers were suspended in a hyaluronic acid (HA) vehicle. Tocopheryl acetate (TA) was loaded into lipid nanoparticles (TALN) that were <100 nm in size and physically stable for more than 28 days. The TALN interacted with the HA polymeric chains to increase formulation macroviscosity. Nanoparticle tracking analysis confirmed that the gel hindered the TALN mobility. However, deliberate manipulation of the particle mobility in the gel by varying the concentration of HA had little effect on TA delivery. Only ca. 10 μg/cm2 of administered TA was delivered into porcine skin regardless of the vehicle characteristics and this suggested that drug release from the LN was the rate limiting step in the delivery process and not the nanoparticle–vehicle–skin interactions.

Official Website:http://dx.doi.org/10.1016/j.ijpharm.2010.08.012
Type of Research:Article
Publisher/Broadcaster/Company:Elsevier
Your affiliations with UAL:Colleges > London College of Fashion
Date:November 2010
Digital Object Identifier:doi:10.1016/j.ijpharm.2010.08.012
Projects or Series:Research Outputs Review (April 2010 - April 2011)
ID Code:4120
Deposited By:INVALID USER
Deposited On:31 May 2011 15:02
Last Modified:20 Mar 2014 12:19
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