Tasic-Kostov, Marija and Savić, Snezana and Lukic, Milica and Tamburic, Slobodanka and Pavlovic, Milos and Vuleta, Gordana (2010) Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid. Journal of Cosmetic Dermatology, 9 (1). pp. 3-10. ISSN 1473-2130
|Type of Research:||Article|
|Creators:||Tasic-Kostov, Marija and Savić, Snezana and Lukic, Milica and Tamburic, Slobodanka and Pavlovic, Milos and Vuleta, Gordana|
Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles – gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated.
Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks.
Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.
|Your affiliations with UAL:||Colleges > London College of Fashion|
|Digital Object Identifier:||10.1111/j.1473-2165.2010.00474.x|
|Projects or Series:||Research Outputs Review (April 2010 - April 2011)|
|Date Deposited:||31 May 2011 14:31|
|Last Modified:||07 Oct 2015 17:55|
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