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UAL Research Online

Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands

Williams, Stefanie and Tamburic, Slobodanka and Stensvik, Henriette and Weber, Mateja (2009) Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands. Journal of Cosmetic Dermatology, 8 (3). pp. 216-225. ISSN 1473-2130

Type of Research: Article
Creators: Williams, Stefanie and Tamburic, Slobodanka and Stensvik, Henriette and Weber, Mateja
Description:

Background  Up to now rejuvenating treatment of the hands has been challenging and results often disappointing.

Aims  To determine whether hyaluronic acid (HA) microdroplet placement into the dorsal hands has an impact on skin physiology and clinical appearance and whether there is any difference between stabilized HA (S-HA) and nonstabilized HA (NS-HA).

Patients/methods  The intra-individual comparison in 15 volunteers involved injection sessions at week 0, 4, and 8 with random assignment of left and right hand to either S-HA or NS-HA. Skin physiology parameters cutaneous elasticity, surface roughness, hydration, and transepidermal water loss (TEWL) were measured in vivo at weeks 0 (before treatment), 4 (before subsequent treatment), 12, and 24. Clinical hand assessment was carried out at weeks 0 and 12 by a blinded dermatologist.

Results  Intradermal injection of S-HA generated significant improvement in skin elasticity and surface roughness at week 12 compared to baseline. On the hands treated with NS-HA, there was a trend for improvement (not significant). While there was no significant difference in hydration and TEWL between both hands before treatment, at week 12 hands treated with S-HA displayed a significantly higher hydration level and lower TEWL compared to NS-HA treatment. Clinically S-HA proved to be significantly superior to NS-HA. At week 24 the observed effects started to return back toward baseline, with S-HA treatment still offering better results compared to the NS-HA.

Conclusions  Skin revitalization with injectable HA can improve clinical appearance and skin physiology parameters on the back of the hands. It has been shown that S-HA has better effects when compared with NS-HA.

Official Website: http://dx.doi.org/10.1111/j.1473-2165.2009.00447.x
Publisher/Broadcaster/Company: Wiley-Blackwell
Your affiliations with UAL: Colleges > London College of Fashion
Date: 2009
Digital Object Identifier: 10.1111/j.1473-2165.2009.00447.x
Date Deposited: 01 Jun 2011 14:49
Last Modified: 08 Oct 2015 05:34
Item ID: 4186
URI: https://ualresearchonline.arts.ac.uk/id/eprint/4186

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