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Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability

Savić, Snezana and Tamburic, Slobodanka and Kovacevic, Andjelka and Daniels, Rolf and Muller-Goymann, Christel (2008) Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability. Journal of Dispersion Science and Technology, 29 (9). pp. 1276-1287. ISSN 0193-2691 [Physical Sciences > Cosmetic Science]
 
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Creators:Savić, Snezana and Tamburic, Slobodanka and Kovacevic, Andjelka and Daniels, Rolf and Muller-Goymann, Christel
Description:

There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-crystalline (L) and complex lamellar gel (Lβ) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles.

Official Website:http://dx.doi.org/10.1080/01932690701857558
Type of Research:Article
Publisher/Broadcaster/Company:Taylor & Francis
Your affiliations with UAL:Colleges > London College of Fashion
Date:2008
Digital Object Identifier:doi:10.1080/01932690701857558
ID Code:4189
Deposited By:INVALID USER
Deposited On:01 Jun 2011 15:59
Last Modified:20 Mar 2014 12:30
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