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Tocopheryl acetate disposition in porcine and human skin when administered using lipid nanocarriers

Moddaresi, Mojgan and Brown, Marc B. and Tamburic, Slobodanka and Jones, Stuart A. (2010) Tocopheryl acetate disposition in porcine and human skin when administered using lipid nanocarriers. Journal of Pharmacy and Pharmacology, 62 (6). pp. 762-769. ISSN 20427158 [Physical Sciences > Cosmetic Science]
 
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Creators:Moddaresi, Mojgan and Brown, Marc B. and Tamburic, Slobodanka and Jones, Stuart A.
Description:

Objectives Assessing the delivery of a drug into the skin when it has been formulated within a nanocarrier is a complex process that does not conform to the conventions of traditional semi-solid formulations. The aim of this study was to gain a fundamental understanding of drug disposition in both human and porcine skin when applied using a lipidic nanocarrier.

Methods A model system was generated by loading tocopheryl acetate into a well-characterised solid lipid nanoparticle and formulating this system as a traditional aqueous hyaluronic acid gel. Franz diffusion cells fitted with a silicone or nylon membrane were used to assess drug and particle transport independently whilst human and pig skin were employed to determine skin delivery.

Key findings The tocopheryl acetate, when loaded into the solid lipid nanoparticles, did not release from the particle. However, 1.65 ± 0.90% of an infinite dose of tocopheryl acetate penetrated into the stratum corneum of pig skin when delivered using a nanoparticle-containing gel.

Conclusions These results suggest that hydration of the stratum corneum in pig skin could lead to the opening of hydrophilic pores big enough for 50 nm-sized particles to pass into the superficial layers of the skin, a phenomenon that was not repeated in human skin.

Official Website:http://dx.doi.org/10.1211/jpp.62.06.0013
Type of Research:Article
Publisher/Broadcaster/Company:Wiley-Blackwell
Your affiliations with UAL:Colleges > London College of Fashion
Date:10 June 2010
Digital Object Identifier:doi:10.1211/jpp.62.06.0013
Projects or Series:Research Outputs Review (April 2010 - April 2011)
ID Code:4618
Deposited By:INVALID USER
Deposited On:26 Jan 2012 13:36
Last Modified:20 Mar 2014 12:21
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