|Creators:||Moddaresi, Mojgan and Brown, Marc B. and Tamburić, Slobodanka and Jones, Stuart A.|
Objectives Assessing the delivery of a drug into the skin when it has been formulated within a nanocarrier is a complex process that does not conform to the conventions of traditional semi-solid formulations. The aim of this study was to gain a fundamental understanding of drug disposition in both human and porcine skin when applied using a lipidic nanocarrier.
Methods A model system was generated by loading tocopheryl acetate into a well-characterised solid lipid nanoparticle and formulating this system as a traditional aqueous hyaluronic acid gel. Franz diffusion cells fitted with a silicone or nylon membrane were used to assess drug and particle transport independently whilst human and pig skin were employed to determine skin delivery.
Key findings The tocopheryl acetate, when loaded into the solid lipid nanoparticles, did not release from the particle. However, 1.65 ± 0.90% of an infinite dose of tocopheryl acetate penetrated into the stratum corneum of pig skin when delivered using a nanoparticle-containing gel.
Conclusions These results suggest that hydration of the stratum corneum in pig skin could lead to the opening of hydrophilic pores big enough for 50 nm-sized particles to pass into the superficial layers of the skin, a phenomenon that was not repeated in human skin.
|Type of Research:||Article|
|Your affiliations with UAL:||Colleges > London College of Fashion|
|Date:||10 June 2010|
|Digital Object Identifier:||doi:10.1211/jpp.62.06.0013|
|Projects or Series:||Research Outputs Review (April 2010 - April 2011)|
|Deposited By:||John Murtagh|
|Deposited On:||26 Jan 2012 13:36|
|Last Modified:||08 Feb 2012 11:00|