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UAL Research Online

Topical gels of etofenamate: in vitro and in vivo evaluation

Marto, Joana and Baltazar, Diogo and Duarte, Aida and Fernandes, Ana and Gouveia, Luís and Militao, Maria and Salgado, Ana and Simoes, Sandra and Oliveira, Eduardo and Ribeiro, Helena Margarida (2014) Topical gels of etofenamate: in vitro and in vivo evaluation. Pharmaceutical Development and Technology, 20 (11). pp. 710-715. ISSN 1097-9867

Type of Research: Article
Creators: Marto, Joana and Baltazar, Diogo and Duarte, Aida and Fernandes, Ana and Gouveia, Luís and Militao, Maria and Salgado, Ana and Simoes, Sandra and Oliveira, Eduardo and Ribeiro, Helena Margarida
Description:

Non-steroid anti-inflammatory drugs (NSAIDs), such as etofenamate, are among the most prescribed drugs used for their analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Topical formulations have the main advantage of targeted delivery. However, drugs must overcome the skin due to its role as a physical and chemical barrier against the penetration of chemicals and microorganisms. This barrier must be altered to allow the permeation of drugs at a suitable rate to the desired site of activity. Permeation modulators can intercalate the skin outer layers causing structure disruption, opening an energetically favourable route for the drug to diffuse through. The aim of this work was the development of hydroalcoholic gels containing 5.0% (w/w) of etofenamate for topical administration with antiinflammatory activity and enhanced drug delivery. The physical and chemical characterization, in vitro release and permeation studies and in vivo anti-inflammatory activity were assessed. The gel with 30% ethanol showed in vivo anti-inflammatory activity with suitable physical chemical and microbiologic characteristics. In vitro release and permeation studies revealed that the different amounts of ethanol used influenced the release profiles of etofenamate. Moreover, it was demonstrated that this formulation is an adequate vehicle for the etofenamate skin permeation.

Official Website: https://www.tandfonline.com/doi/abs/10.3109/10837450.2014.915571?journalCode=iphd20
Keywords/subjects not otherwise listed: Pharmaceutics
Publisher/Broadcaster/Company: Informa Healthcare
Your affiliations with UAL: Colleges > London College of Fashion
Date: 5 May 2014
Digital Object Identifier: 10.3109/10837450.2014.915571
Date Deposited: 15 Jun 2018 09:33
Last Modified: 01 Apr 2020 19:47
Item ID: 12753
URI: https://ualresearchonline.arts.ac.uk/id/eprint/12753

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