We use cookies on this website, you can read about them here. To use the website as intended please... ACCEPT COOKIES
UAL Research Online

Skin Barrier Impaired? Two 'TEWLs' to tell

Den, Yi Ann and Tamburic, Slobodanka and Varcin, Mustafa and Searing, Caroline and Chan, Melissa (2017) Skin Barrier Impaired? Two 'TEWLs' to tell. Cosmetics and Toiletries, 132 (1). pp. 42-55.

Type of Research: Article
Creators: Den, Yi Ann and Tamburic, Slobodanka and Varcin, Mustafa and Searing, Caroline and Chan, Melissa

The lipid matrix of the stratum corneum (SC), consisting primarily of ceramides, cholesterol and fatty acids, is crucial for the integrity of the skin barrier. Linoleic acid is an essential fatty acid, whose deficiency can lead to abnormal epidermal permeability barrier function.1, 2 In the case of its deficiency, linoleic acid is replaced with oleic acid, disturbing the normal formation of lipid lamellae in the SC.3

It has been proposed that topical treatment of linoleic acid could repair defective barrier function in detergent-treated skin.1 In addition, it has been shown that topical application of fatty acids in general could alter the intercellular lipid domains of the SC.4 A range of commercial and newly developed topical products containing linoleic acid was therefore used in the present study to assess, via transepidermal water loss (TEWL), the proposed effects:
•The protection potential, whereby the products are applied for a period of time before the insult to the skin barrier is carried out; in this case with sodium lauryl sulfate (SLS) solution; and
•The repair potential, whereby an insult with SLS to the skin barrier was followed by a period of product application.

Official Website: http://www.cosmeticsandtoiletries.com
Additional Information (Publicly available):

Access to this article is restricted due to the publishers' copyright poilcy. Please contact UAL Research Online to request a copy.

Publisher/Broadcaster/Company: Allured Publishing Corp
Your affiliations with UAL: Colleges > London College of Fashion
Date: 3 January 2017
Date Deposited: 28 Apr 2017 12:27
Last Modified: 01 Apr 2020 19:41
Item ID: 10720
URI: https://ualresearchonline.arts.ac.uk/id/eprint/10720

Repository Staff Only: item control page | University Staff: Request a correction