Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data

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Ferland, Jacqueline-Marie and Ellis, Randall and Betts, Graeme and Silveira, Mason and Bronze de Firmino, Joao and Winstanley, Catharine and Hurd, Yasmin (2022) Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data. JAMA Psychiatry, 80 (1). ISSN 2168-6238

Type of Research:	Article
Creators:	Ferland, Jacqueline-Marie and Ellis, Randall and Betts, Graeme and Silveira, Mason and Bronze de Firmino, Joao and Winstanley, Catharine and Hurd, Yasmin
Description:	Question: Is there an association between adolescent high-dose Δ9-tetrahydrocannabinol (THC) exposure and cognitive vulnerability in adulthood? Findings: In this rat model, high-dose THC exposure during adolescence resulted in risky decision-making and impulsivity in adulthood, similar to results from reanalyzed data from 37 human chronic cannabis users, an association enhanced by acute THC reexposure. Adolescent THC exposure induced cell-specific and layer-specific changes in cannabinoid-1 receptor gene expression and astrocyte perturbations in the amygdala and prelimbic cortex. Meaning: These results emphasize significant neurobiological outcomes of high-dose adolescent THC exposure and cognitive vulnerability in adulthood.
Official Website:	https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2799065
Your affiliations with UAL:	Colleges > London College of Fashion
Date:	23 November 2022
Digital Object Identifier:	10.1001/jamapsychiatry.2022.3915
Date Deposited:	29 May 2026 09:19
Last Modified:	29 May 2026 09:19
Item ID:	26848
URI:	https://ualresearchonline.arts.ac.uk/id/eprint/26848
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