Structural characterization of multiphase emulsion systems based on an alkylpolyglucosode non-ionic emulsifier

The aim of this study Was to Examine the lyotropic potential of an alkylpolyglucoside mixed Emulsifier (Cetearyl Glucoside & Cetearyl alcohol), Which Belongs to the new generation of natural (sugar) surfactants, and to elaborate the stabilization mechanism and relation Between the colloid microstructure and water distribution Within the systems. Polarization and ordinary light as well as transmission electron microscopy, wide angle X-ray diffraction, thermal analysis and rheological measurement, as well as in vivo hydration potential Were employed for testing the systems Characterization. A comparison of results Obtained from Isothermal thermogravimetry and in vivo short-term application study served to Recognize Within water distribution systems and the dynamic of water evaporation, ie to consider in the Possibility of Formulation and Prolonged water emulsion with controlled release.

It Was Suggested That Cetearyl glucoside & Cetearyl alcohol stabilizes the o / w creams by synergistic effects of Viscoelastic Hydrophilic Lamellar type of gel and lipophilic gel network built up from semi-Cetostearyl alcohol hydrates as well as by Lamellar liquid crystalline bilayers surrounding the oil droplets. Generally, in creams based on the non-ionic Emulsifier alkylpolyglucoside MontanovÒ 68 PHA four fractions of water Could Be Met: 1) free - bulk water, 2) Within lipophilic gel bonded water (secondary water), 3) water interlamelarilly Between fixed crystalline lipid bilayers (Hydrophilic gel) and 4) water Between fixed lipid layers in liquid-crystalline state.

It is Also Showed That Additions oil into The Chosen binary system microstructure Significantly Influences the creams, Which Reflects Particularly onto the mode of water distribution and consequently Their creams Within The potential of skin hydration. Thus, the model with Emulsifier cream / water ratio of 1:10:43 and 20% medium chain triglycerides as oil phase Was selected as optimal model Formulation with Prolonged pronounced potential for skin hydration.